Liquid metal biomaterials for biomedical imaging.

Liquid metals (LMs) not only retain the basic properties of metallic biomaterials, such as high thermal conductivity and high electrical conductivity, but also possess flexibility, flowability, deformability, plasticity, good adhesion, and so on. Therefore, they open many possibilities of extending soft metals into biomedical sciences including biomedical imaging. One of the special properties of LMs is that they can provide a controllable material system in which the electrical, thermal, mechanical, and chemical properties can be controlled on a large scale. This paper reviews the preparation and characteristics of LM-based biomaterials classified into four categories: LM micro/nanoparticles, surface modified LM droplets, LM composites with inorganic substances, and LM composites with organic polymers. Besides, considering the most important requirement for biomaterials is biocompatibility, the paper also analyzes the toxicity results of various LM biomaterials when used in the biomedical area, from different levels including body weight measurement, histology evaluation, and blood biochemistry tests. Next, the applications of LMs in X-ray, CT, MRI, photoacoustic imaging, and molecular imaging are introduced in detail. And finally, the challenges and opportunities of their application in medical imaging are also discussed.