Evaluation of a Prognostic Epigenetic Classification System in Chronic Lymphocytic Leukemia Patients.

Christina GrimmCarmen Diana HerlingAnastasia KomnidiMichelle HussongKarl-Anton KreuzerMichael HallekMichal R Schweiger

Published in: Biomarker insights (2022)

= .0008). In addition, when comparing the prognostic value of the epigenetic classification system with the IGHV classification, epigenetic grouping performed better compared to IGHV mutational status using Kaplan-Meier estimation and allowed the identification of a third, intermediate (i-CLL) group. Thus, our study confirmed the prognostic value of the epigenetic marker set for patient stratification in routine clinical diagnostics.

Keyphrases

dna methylation
chronic lymphocytic leukemia
gene expression
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
machine learning
deep learning
peritoneal dialysis
case report
clinical practice