Pre-Clinical Evaluation of Tenofovir and Tenofovir Alafenamide for HIV-1 Pre-Exposure Prophylaxis in Foreskin Tissue.

Laura ElseSujan D PenchalaAzure-Dee PillayThabiso B SeiphetloLimakatso LebinaChristian CallebautSuks MinhasRoland MorleyTina RashidNeil MartinsonJulie M Fox Saye H Khoo Carolina Herreranull null

Published in: Pharmaceutics (2022)

Pre-clinical evaluation of TAF in foreskin explants revealed greater potency than TFV against penile HIV transmission. Clinical evaluation is underway to support this finding.

Keyphrases

clinical evaluation
antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hiv aids
hiv testing
hepatitis c virus
men who have sex with men
single cell
prostate cancer
south africa
radical prostatectomy