A Possible Modifying Effect of the G2019S Mutation in the LRRK2 Gene on GBA Parkinson's Disease.

Nurit OmerNir GiladiTanya GurevichAnat Bar-ShiraMali Gana-WeiszOrly GoldsteinMeir KestenbaumJesse M CedarbaumAvi Orr-UrtregerAnat MirelmanAvner Thaler

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Patients with LRRK2+GBA-PD were symptomatically similar to patients with LRRK2-PD, suggesting a dominant effect of LRRK2 over GBA in the phenotypic presentation. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

genome wide
copy number
gene expression
transcription factor