Siderophore-harboring gut bacteria and fecal siderophore genes for predicting the responsiveness of fecal microbiota transplantation for active ulcerative colitis.

Jingshuang YanGuanzhou ZhouRongrong RenXiaohan ZhangNana ZhangZikai WangLihua PengYun-Sheng Yang

Published in: Journal of translational medicine (2024)

A significant increase in Faecalibacterium, and decrease in Enterobacteriaceae and the total fecal siderophore genes copy number were observed in responders after FMT. The siderophore genes and its encoding bacteria may be of predictive value for the clinical responsiveness of FMT to active ulcerative colitis.

Keyphrases

ulcerative colitis
genome wide
copy number
mitochondrial dna
dna methylation
bioinformatics analysis
genome wide identification
genome wide analysis
stem cells
gene expression
transcription factor
mesenchymal stem cells
cell therapy
bone marrow