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Notch signaling regulates Th17 cells differentiation through PI3K/AKT/mTORC1 pathway and involves in the thyroid injury of autoimmune thyroiditis.

C HeY LiL GanY LinB ZhangLei MaHaibo Xue
Published in: Journal of endocrinological investigation (2024)
Notch signal promotes the secretion of IL-17A from Th17 cells by regulating the downstream PI3K/AKT/mTORC1 pathway through Hes-Phosphatase and tensin homolog (PTEN) and participates in thyroid autoimmune damage, and the PI3K pathway inhibitor may play important effects on AIT by affecting Th17 cells differentiation.
Keyphrases
  • cell cycle arrest
  • pi k akt
  • signaling pathway
  • induced apoptosis
  • cell proliferation
  • cell death
  • oxidative stress
  • multiple sclerosis
  • endoplasmic reticulum stress
  • drug induced