Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development.

Sarah WyckCarolina HerreraCristina E RequenaLilli BittnerPetra HajkovaHeinrich BollweinRaffaella Santoro

Published in: Epigenetics & chromatin (2018)

The data demonstrate that oxidative stress in sperm has an impact not only on DNA integrity but also on the dynamics of epigenetic reprogramming, which may harm the paternal genetic and epigenetic contribution to the developing embryo and affect embryo development and embryo quality.

Keyphrases

oxidative stress
dna methylation
gene expression
pregnancy outcomes
dna damage
genome wide
electronic health record
induced apoptosis
single molecule
machine learning