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Synthesis of Unsymmetrical Diarylfumaronitriles via Tandem Michael Addition and Oxidation under K 3 Fe(CN) 6 /O 2 System.

Chongjiu LuMin YeLipeng LongYue ZhengJiameng LiuYue ZhangZhengwang Chen
Published in: The Journal of organic chemistry (2022)
An efficient formal alkenyl C-H cyanation reaction has been developed for the general synthesis of unsymmetrical diarylfumaronitriles in good to excellent yields. The reaction was achieved through tandem Michael addition and an oxidative process. The merits of this transformation include the use of K 3 Fe(CN) 6 as a safe and nontoxic cyanide source, without an external noble metal catalyst, oxygen-involved reactions, easily available raw materials, good functional group tolerance, high stereoselectivity, and potential further application of the products.
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