Oncogenic tRNA-derived fragment tRF-Leu-CAG promotes tumorigenesis of lung cancer via targeting TCEA3 and increasing autophagy.

Fan WuBinshu ChaiPengfei QiYaqi HanZhitao GuWei PanHui ZhangXianyi WangXiaomin LiuHeng ZouChen LiangYanLi LiWentao FangZhong-Liang Ma

Published in: The journal of gene medicine (2024)

tRF-Leu-CAG promotes NSCLC tumor growth and metastasis by targeting TCEA3 and promotes paclitaxel resistance by enhancing cellular autophagy. These results provide potentially effective targets and therapeutic options for the clinical treatment of NSCLC.

Keyphrases

small cell lung cancer
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
drug delivery
brain metastases
replacement therapy