TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway.
Tianqi LuZiqi ZhangZhenfei BiTianxia LanHao ZengYu LiuFei MoJingyun YangSiyuan ChenXuemei HeWeiqi HongZhe ZhangRuyu PiWenyan RenXiaohe TianYuquan WeiMin LuoYanping QianPublished in: Journal for immunotherapy of cancer (2023)
We have revealed that TFAM knockout in DCs ameliorated immune-suppressive microenvironment in tumors through STING pathway. Our work suggests that specific TFAM knockout in DCs might be a compelling strategy for designing novel immunotherapy methods in the future.