[A Case Report of Acute Angioedema that Showed Dramatic Response to Administration of a C1-inactivator].
Hiroe TadaToshiyuki MatsuyamaTakeshi KudoKazuaki ChikamatsuPublished in: Nihon Jibiinkoka Gakkai kaiho (2018)
Angioedema is characterized by rapid and severe swelling of the subcutaneous and submucosal tissues. Angioedema
involving the upper airway can lead to life-threatening airway obstruction, and needs prompt diagnosis and treatment.
Herein, we report a case of acute angioedema which was suspected as having been caused by estrogen imbalance. A
32-year-old woman who was taking a fertility drug for infertility treatment, presented with sudden swelling of the face and
neck region and breathing difficulty. Her symptoms continued to progress despite antibiotic and corticosteroid
administration. We suspected hereditary angioedema (HAE), and administered a C1-inactivator, which led to immediate
and dramatic resolution of the symptoms. Since the C4 and C1-inhibitor levels were normal, the possibility of HAE type
III was considered. However, another possibility was that her complicated hormonal condition, including oral intake of a
fertility drug, menstruation, and mental stress may have led to estrogen imbalance causing angioedema. Currently, a
variety of hormone therapies is widely used ; therefore, caution is needed against the development of estrogen-dependent
angioedema.
Keyphrases
- angiotensin converting enzyme
- angiotensin ii
- drug induced
- liver failure
- type iii
- pulmonary embolism
- respiratory failure
- gene expression
- sleep quality
- intensive care unit
- type diabetes
- hepatitis b virus
- depressive symptoms
- polycystic ovary syndrome
- skeletal muscle
- quantum dots
- weight loss
- body mass index
- acute respiratory distress syndrome
- weight gain