Catalytic Enantioselective Birch-Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters.
Andrew T KrasleyWilliam P MalachowskiHannah M TerzSabrina Tran TienPublished in: Organic letters (2018)
A new enantioselective desymmetrizing Mizoroki-Heck reaction is reported. The process affords high yields and enantioselectivities of tricyclic structures containing all-carbon quaternary stereocenters. The substrates for the reaction are efficiently synthesized from Birch reduction-alkylation of benzoic acid and benzoate esters.
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