Macrostructural Brain Abnormalities in Spinal Muscular Atrophy: A Case-Control Study.

Emilie Groulx-BoivinAndrea Oliveira-CarneiroHelen L CarlsonAmalia FloerAdam Kirton Jean K Mah Christine Saint-Martin Roberta La Piana Maryam Oskoui

Published in: Neurology. Genetics (2024)

Individuals with SMA have higher rates of macrostructural brain abnormalities than their neurotypical peers, suggesting CNS involvement in SMA. Understanding changes in the brain architecture of the SMA population can inform the development of adjunct therapies targeting the CNS and potentially guide rehabilitation strategies.

Keyphrases

resting state
white matter
functional connectivity
blood brain barrier
cerebral ischemia
multiple sclerosis
brain injury