Sensitivity of Volumetric Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy to Progression of Spinocerebellar Ataxia Type 1.
Dinesh K DeelchandJames M JoersAdarsh RavishankarTianmeng LyuUzay E EmirDiane HutterChristopher M GomezKhalaf O BusharaChristophe LengletLynn E EberlyGülin ÖzPublished in: Movement disorders clinical practice (2019)
Both MRI and MRS were more sensitive to disease progression than SARA in SCA1. Pontine volume was most sensitive to change, whereas MRS may have more sensitivity at the premanifest stage and predictive value for disease progression.