Cholesterol absorption blocker ezetimibe prevents muscle wasting in severe dysferlin-deficient and mdx mice.

Zoe White Marine TheretNadia MiladLin Wei TungWilliam Wei-Han ChenMartin G SiroisFabio M V Rossi Pascal Bernatchez

Published in: Journal of cachexia, sarcopenia and muscle (2021)

Cholesterol exacerbates rodent MD. Specific inhibition of cholesterol absorption with ezetimibe may safely attenuate human MD severity and delay death.

Keyphrases

low density lipoprotein
endothelial cells
molecular dynamics
skeletal muscle
duchenne muscular dystrophy
early onset
induced pluripotent stem cells
high fat diet induced
mouse model
wild type
angiotensin converting enzyme
drug induced
insulin resistance