Meroantarctines A-C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity.
Elena V LeshchenkoAlexandr S AntonovSergey A DyshlovoyDmitrii V BerdyshevJessica HauschildOlesya I ZhuravlevaGleb V BorkunovAlexander S MenshovNatalya N KirichukRoman S PopovAndrey V GerasimenkoAnatoly A UdovenkoMarkus GraefenCarsten BokemeyerGunhild von AmsbergAnton Nikolaevich YurchenkoPublished in: Journal of natural products (2022)
New meroterpenoids, meroantarctines A-C ( 1 - 3 ), with unique 6/5/6/6, 6/5/6/5/6, and 6/5/6/5 polycyclic systems were isolated from the alga-derived fungus Penicillium antarcticum KMM 4685. Their structures were elucidated by spectroscopic methods, X-ray diffraction, and quantum chemical calculations. A biogenetic pathway for 1 - 3 was proposed. Meroantarctines A-C ( 1 - 3 ) inhibited p-glycoprotein activity and could resensitize drug-resistant cancer cells to docetaxel.