Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial.

Anthony J Garcia-PratsElin M SvenssonJana WincklerHeather R DraperLee FairlieLouvina E van der LaanMasebole MasenyaPawel T Schubert Lubbe WiesnerJennifer NormanRob E AarnoutseMats O KarlssonPaolo DentiAnneke C Hesseling

Published in: The Journal of antimicrobial chemotherapy (2021)

High rifampicin doses in children achieved target exposures and the doses evaluated were safe over 2 weeks.

Keyphrases

mycobacterium tuberculosis
high dose
pulmonary tuberculosis
young adults
low dose
air pollution
study protocol
stem cell transplantation
phase iii