DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas.
Sandra Ferreyra VegaThomas Olsson BontellAlba CorellAnja SmitsAsgeir Store JakolaHelena CarénPublished in: Clinical epigenetics (2021)
The stratification of the patients by methylation profiling was as effective as the integrated WHO 2016 molecular reclassification at predicting the clinical outcome of the patients. Our study shows that DNA methylation profiling is a reliable and robust approach for the classification of dLGG into molecular defined subgroups, providing accurate detection of molecular markers according to WHO 2016 classification.
Keyphrases
- dna methylation
- end stage renal disease
- machine learning
- newly diagnosed
- ejection fraction
- deep learning
- chronic kidney disease
- gene expression
- genome wide
- peritoneal dialysis
- single cell
- prognostic factors
- young adults
- patient reported outcomes
- high grade
- sensitive detection
- loop mediated isothermal amplification
- label free