5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.

Eva Christine BunkAndrea WagnerWalter StummerVolker SennerBenjamin Brokinkel

Published in: Journal of neuro-oncology (2021)

Eligibility of established meningioma cell lines for in-vitro analyzes of tumor fluorescence significantly differs. Fluorescence in Ben-Men 1 and primary meningioma cell lines but less in IOMM Lee cells is 5-ALA dose-dependent, encouraging in-situ trials to encounter currently discussed shortcomings of FGS in meningiomas. Fluorescence is not related to expression of FECH, ABCB6 and ABCG2.

Keyphrases

high grade
single molecule
energy transfer
low grade
induced apoptosis
cell cycle arrest
oxidative stress
middle aged
cell death
long non coding rna
quantum dots