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5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.

Eva Christine BunkAndrea WagnerWalter StummerVolker SennerBenjamin Brokinkel
Published in: Journal of neuro-oncology (2021)
Eligibility of established meningioma cell lines for in-vitro analyzes of tumor fluorescence significantly differs. Fluorescence in Ben-Men 1 and primary meningioma cell lines but less in IOMM Lee cells is 5-ALA dose-dependent, encouraging in-situ trials to encounter currently discussed shortcomings of FGS in meningiomas. Fluorescence is not related to expression of FECH, ABCB6 and ABCG2.
Keyphrases
  • high grade
  • single molecule
  • energy transfer
  • low grade
  • induced apoptosis
  • cell cycle arrest
  • oxidative stress
  • middle aged
  • cell death
  • long non coding rna
  • quantum dots