CircSLC7A2 protects against osteoarthritis through inhibition of the miR-4498/TIMP3 axis.

Weiyu NiChao JiangYizheng WuHaitao ZhangLili WangJasper H N YikDominik R HaudenschildShunwu FanShuying ShenZiang Hu

Published in: Cell proliferation (2021)

The circSLC7A2/miR-4498/TIMP3 axis of chondrocytes catabolism and anabolism plays a critical role in OA development. Our results suggest that circSLC7A2 may serve as a new therapeutic target for osteoarthritis.

Keyphrases

cell proliferation
long non coding rna
knee osteoarthritis
long noncoding rna
rheumatoid arthritis