Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells.

Yong-Hee ChoEun Ji RoJeong-Su YoonDong-Kyu KwakJaebeom ChoDong Woo KangHo-Young LeeKang-Yell Choi

Published in: Cell communication and signaling : CCS (2020)

Our results suggest that destabilization of both β-catenin and RAS is a potential therapeutic strategy for controlling stemness of CRC cells. Video abstract.

Keyphrases

epithelial mesenchymal transition
small molecule
induced apoptosis
stem cells
wild type
signaling pathway
cell proliferation
cell cycle arrest
high glucose
diabetic rats
protein protein
endoplasmic reticulum stress
cancer stem cells
single molecule