Biomedically Relevant Self-Assembled Metallacycles and Metallacages.
Hajar SepehrpourWenxin FuYan SunPeter J StangPublished in: Journal of the American Chemical Society (2019)
Diverse metal-organic complexes (MOCs), shaped as rectangles, triangles, hexagons, prisms, and cages, can be formed by coordination between metal ions (Pt, Pd, Ru, Rh, Ir, Zn, Co, and Cd) and organic ligands, with potential applications as alternatives to conventional biomedical materials for therapeutic, sensing, and imaging purposes. MOCs have been investigated as anticancer drugs in the treatment of malignant tumors in lung, cervical, breast, colon, liver, prostate, ovarian, brain, stomach, bone, skin, mouth, thyroid, and other cancers. MOCs with one, two, and three cavities have also been investigated as drug carriers and prepared for the loading and release of different drugs. In addition, MOCs can target proteins by the shape effect and recognize sugars and DNA by electrostatic interactions, as well as estradiol by host-guest interactions, etc. This Perspective mainly covers achievements in the biomedical application of MOCs. We aim to identify some key trends in the reported MOC structures in relation to their biomedical activity and potential applications.
Keyphrases
- water soluble
- high resolution
- prostate cancer
- soft tissue
- atomic force microscopy
- heavy metals
- human health
- drug induced
- single molecule
- bone mineral density
- circulating tumor
- emergency department
- quantum dots
- mass spectrometry
- molecular dynamics simulations
- benign prostatic hyperplasia
- risk assessment
- multiple sclerosis
- postmenopausal women
- photodynamic therapy
- cerebral ischemia
- bone regeneration
- replacement therapy
- energy transfer