In vivo evaluation of monoclonal antibody M4M using a humanised rat model of stroke demonstrates attenuation of reperfusion injury via blocking human TRPM4 channel.

Charlene Priscilla PooreShunhui WeiBo ChenSee Wee LowJeslyn Si Qi TanAndy Thiam-Huat LeeBernd NiliusPing Liao

Published in: Journal of drug targeting (2024)

M4M selectively binds and inhibits hypoxia-induced human TRPM4 channel activation in neurons from the humanised rat model, with no effect on healthy neurons. Use of M4M in stroke rats showed functional improvements, suggesting the potential for anti-human TRPM4 antibodies in treating acute ischaemic stroke patients.

Keyphrases

endothelial cells
monoclonal antibody
induced pluripotent stem cells
atrial fibrillation
spinal cord
heart failure
cerebral ischemia
spinal cord injury
acute myocardial infarction
left ventricular
extracorporeal membrane oxygenation
mechanical ventilation