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Voluntary adolescent alcohol exposure does not increase adulthood consumption of alcohol in multiple mouse and rat models.

Avery R SicherAndrea LissValentina VozellaLaurel R SeemillerMatthew SpringerWilliam D StarnesKeith R GriffithGrace C SmithAmy AstefanousMarisa RobertoFlorence P VarodayanNicole A Crowley
Published in: bioRxiv : the preprint server for biology (2024)
Adolescent drinking-in-the-dark (DID) binge drinking does not increase adulthood consumption in a DID model or a two bottle choice model in male and female SST-Cre:Ai9 miceAdolescent pair-housed intermittent access consumption of alcohol does not increase adulthood consumption in an identical adulthood model in male and female C57BL/6J miceAdolescent intermittent access to alcohol does not increase adulthood consumption in male and female Wistar ratsThese complementary datasets across murine models and institutions highlight the need to consider human social factors as well as biological factors.
Keyphrases
  • alcohol consumption
  • depressive symptoms
  • early life
  • mental health
  • young adults
  • endothelial cells
  • healthcare
  • high intensity
  • oxidative stress
  • machine learning
  • rna seq
  • deep learning
  • decision making
  • single cell