The transcriptome characteristics of vestibular organs from delayed endolymphatic hydrops patients (Meniere's disease).

Bin-Jun ChenWen-Wei LuoWei-Dong ZhaoXiao-Qing QianYan-Mei WangYu ZhengXin-Wei WangXin-da XuYa-Sheng YuanFang-Lu ChiDong-Dong Ren

Published in: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (2021)

The protein expression profile of vestibular organs in patients with endolymphatic hydrops exhibited a degree of similarity to that of Ménière's disease. Endolymphatic hydrops is characterised by autoimmune abnormalities. DEH and Ménière's disease are likely to be different manifestations of the same disease, with disparate clinical symptoms. RNA-Seq is a useful analytical tool to characterise the vestibular pathology based on its transcriptome.

Keyphrases

rna seq
single cell
end stage renal disease
gene expression
chronic kidney disease
multiple sclerosis
ejection fraction
small molecule
binding protein
protein protein
sleep quality