Impact of selection bias on polygenic risk score estimates in healthcare settings.
Younga Heather LeeTanayott ThaweethaiYi-Han SheuYen-Chen Anne FengElizabeth W KarlsonTian GePeter KraftJordan W SmollerPublished in: Psychological medicine (2023)
Non-random selection of participants into volunteer biobanks may induce clinically relevant selection bias that could impact implementation of PRS in research and clinical settings. As efforts to integrate PRS in medical practice expand, recognition and mitigation of these biases should be considered and may need to be optimized in a context-specific manner.