PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer.

Ghaneya Al-KhadairiAdviti NaikRemy ThomasBoshra Al-SulaitiShaheen RizlyJulie V Decock

Published in: Journal of translational medicine (2019)

Our findings indicate that PRAME plays a tumor-promoting role in triple negative breast cancer by increasing cancer cell motility through EMT-gene reprogramming. Therefore, PRAME could serve as a prognostic biomarker and/or therapeutic target in TNBC.

Keyphrases

epithelial mesenchymal transition
genome wide
copy number
genome wide identification
gene expression
escherichia coli
signaling pathway
pseudomonas aeruginosa
staphylococcus aureus
cystic fibrosis
candida albicans
genome wide analysis