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Integrated analysis of the aging brain transcriptome and proteome in tauopathy.

Carl Grant MangleburgTimothy WuHari K YalamanchiliCaiwei GuoYi-Chen HsiehDuc M DuongEric B DammerPhilip L De JagerNicholas T SeyfriedZhandong LiuJoshua M Shulman
Published in: Molecular neurodegeneration (2020)
Our results comprise a powerful, cross-species functional genomics resource for tauopathy, revealing Tau-mediated disruption of gene expression, including dynamic, age-dependent interactions between the brain transcriptome and proteome.
Keyphrases
  • gene expression
  • single cell
  • resting state
  • rna seq
  • white matter
  • genome wide
  • dna methylation
  • functional connectivity
  • cerebral ischemia
  • cerebrospinal fluid
  • multiple sclerosis