Integrated analysis of the aging brain transcriptome and proteome in tauopathy.
Carl Grant MangleburgTimothy WuHari K YalamanchiliCaiwei GuoYi-Chen HsiehDuc M DuongEric B DammerPhilip L De JagerNicholas T SeyfriedZhandong LiuJoshua M ShulmanPublished in: Molecular neurodegeneration (2020)
Our results comprise a powerful, cross-species functional genomics resource for tauopathy, revealing Tau-mediated disruption of gene expression, including dynamic, age-dependent interactions between the brain transcriptome and proteome.