1α,25-Dihydroxyvitamin D3 Encapsulated in Nanoparticles Prevents Venous Neointimal Hyperplasia and Stenosis in Porcine Arteriovenous Fistulas.

Avishek K SinghChuanqi Cai Sreenivasulu KilariChenglei ZhaoMichael L SimeonEdwin TakahashiElazer R EdelmanHyunjoon Joon KongThanila MacedoRavinder J SinghMatthew W UrbanRajiv KumarSanjay Misra

Published in: Journal of the American Society of Nephrology : JASN (2021)

Local release of 1,25 NP improves AVF flow and hemodynamics, and reduces stenosis in association with reduction in inflammation, apoptosis, and fibrosis in a porcine model of arteriovenous fistula.

Keyphrases

oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell death
vascular smooth muscle cells
cell proliferation
liver fibrosis
angiotensin ii
pi k akt