Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients.
Elias Paolo CasulaIlaria BorghiMichele MaiellaMaria C PellicciariSonia BonnìLucia MencarelliMartina AssognaAlessia D'AcuntoFrancesco Di LorenzoDanny A SpampinatoEmiliano SantarnecchiAlessandro MartoranaGiacomo KochPublished in: Annals of neurology (2022)
Our data provide novel evidence that precuneus cortical hyperexcitability is a key feature of synaptic dysfunction in patients with AD. The current results point to the combined approach of TMS and EEG as a novel promising technique to measure hyperexcitability in patients with AD. This index could represent a useful biomarker to stage disease severity and evaluate response to novel therapies. ANN NEUROL 2022.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- machine learning
- oxidative stress
- functional connectivity
- cognitive decline
- transcranial magnetic stimulation
- patient reported outcomes
- deep learning
- electronic health record
- resting state
- big data
- high frequency
- artificial intelligence
- mild cognitive impairment