HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.

Yi-Fu HeXi-Min HuMd Asaduzzaman KhanBo-Yao YuYi-Cun ShengXian-Zhong XiaoXin-Xing Wan Si-Pin Tan Kun Xiong

Published in: Mediators of inflammation (2023)

These results imply that HSF1 could alleviate sepsis-induced brain injury by inhibiting pyroptosis through the NLRP3-dependent pathway in brain tissue and PC12 cells, suggesting HSF1 as a potential molecular target for treating brain injury in sepsis clinical studies.

Keyphrases

brain injury
cerebral ischemia
resting state
nlrp inflammasome
heat shock
acute kidney injury
white matter
septic shock
intensive care unit
subarachnoid hemorrhage
high glucose
diabetic rats
functional connectivity
signaling pathway
risk assessment
heat stress
mouse model
heat shock protein