Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum.
Gemma SalvadóMarta Milà-AlomàMahnaz ShekariNicholas J AshtonGrégory OpertoCarles FalconRaffaele CacciagliaCarolina MinguillonKarine FauriaAida Niñerola-BaizánAndrés PerissinottiAndréa L BenedetGwendlyn KollmorgenIvonne SuridjanNorbert WildJosé Luis MolinuevoHenrik ZetterbergKaj BlennowMarc Suárez-CalvetJuan-Domingo Gispertnull nullPublished in: European journal of nuclear medicine and molecular imaging (2022)
Higher astrocytic reactivity, probably in response to early AD pathological changes, is related to higher glucose consumption. With the onset of tau pathology, the observed uncoupling between astrocytic biomarkers and glucose consumption might be indicative of a failure to sustain the higher energetic demands required by reactive astrocytes.