Acid/base responsive assembly/dis-assembly of a family of zirconium(IV) clusters with a cyclic imide-dioxime ligand.

The hydrolytically stable dioxime ligand (2 Z -6 Z )-piperidine-2,6-dione (H 3 pidiox) acts as a strong chelator mainly with hard metals in high oxidation states, a pre-requisite for potential applications in metal sequestering processes from aqueous solutions. Reaction of ZrCl 4 with H 3 pidiox in methanol gives the mononuclear compound [Zr IV (η 1 ,η 1 ,η 2 -H 2 pidiox- O , N , O ') 2 (OH 2 ) 2 ]Cl 2 ·H 2 O·CH 3 OH (1), while the same reaction mixture in the presence of KOH gave the pentanuclear ZrOC [ZrIV5(μ 2 -OH) 4 (OH 2 ) 4 (μ 2 -η 1 ,η 1 ,η 2 -Hpidiox- O , N , O ') 4 (η 1 ,η 1 ,η 1 -Hpidiox O , N , O ') 4 ]·5KCl·3CH 3 OH·8H 2 O (2). Compound 1 is formed at very acidic pH = 0, and the pentanuclear ZrOC 2 at higher pH values (pH = 2). Compounds 1 and 2 were characterized by single crystal X-ray structure analysis, multi-nuclear NMR spectroscopy and ESI-MS spectrometry. The single crystal X-ray structure analysis of 1 revealed a mononuclear zirconium(IV) compound containing an eight-coordinate zirconium atom bound to two singly deprotonated H 2 pidiox - ligands and two water molecules in a severely distorted bicapped octahedral geometry. The pentanuclear ZrOC 2 constitutes the second example of a Zr 5 cluster to be reported and the first one in which the four zirconium atoms are arranged in a tetrahedral arrangement with the fifth occupying the center of the tetrahedron. 1D and 2D NMR spectroscopies of the acidic CD 3 OD solutions of complex 1 reveal a fast equilibrium between 1 and 2. Addition of KOH into a CH 3 OH solution of 2 results in the controlled fast transformation of 2 to an asymmetric hexanuclear ZrOC 3 as evidenced by the NMR and real-time ESI-MS solution studies. Further addition of KOH to the solution of 3 leads to the ZrOC 4, and on the basis of NMR and ESI-MS data and in comparison with the known hexanuclear titanium(IV)/H 3 pidiox cluster, it is concluded that the cluster 4 should have a hexanuclear structure. Electrospray ionization mass spectrometry (ESI-MS) demonstrated not only the structural stability 1 and 2 in solution, but also revealed the reversible pH driven dis-assembly/re-assembly process between the monomeric 1 and the pentanuclear ZrOC 2.