African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
Charles WashingtonMatthew DapasArjun BiddandaKevin M MagnayeIvy AneasBritney A HellingBrooke SzczesnyMeher Preethi BoorgulaMargaret A TaubEimear KennyRasika A MathiasKathleen C Barnesnull nullGurjit K Khurana HersheyCarolyn M KercsmarJessica D GereigeMelanie MakhijaRebecca S GruchallaMichelle A GillAndrew H LiuDeepa RastogiWilliam BussePeter J GergenCynthia M VisnessDiane R GoldTina HartertChristine C JohnsonRobert F LemanskeFernando D MartinezRachel L MillerDennis OwnbyChristine M SeroogyAnne L WrightEdward M ZorattiLeonard B BacharierMeyer KattanGeorge T O'ConnorRobert A WoodMarcelo A NobregaMatthew C AltmanDaniel J JacksonJames E GernChristopher G McKennanCarole OberPublished in: Genome medicine (2022)
Previously unknown genetic variation at the 17q12-21 childhood-onset asthma locus contributes to asthma severity in individuals with African ancestries. We suggest that many other population-specific variants that have not been discovered in GWAS contribute to the genetic risk for asthma and other common diseases.