Whole-exome sequencing reveals the metastatic potential of hepatocellular carcinoma from the perspective of tumor and circulating tumor DNA.

Chenhao ZhouJialei WengShaoqing LiuQiang ZhouZhiqiu HuYirui YinPeng LvJialei SunHui LiYong YiYinghao ShenQinghai YeYi ShiQiongzhu DongChunxiao LiuXiaoqiang ZhuJialei Weng

Published in: Hepatology international (2023)

We characterized the genomic alterations during HCC vascular invasion and revealed a previously undescribed evolution pattern of ctDNA in HCC. A novel multiomics-based signature was developed to identify high-risk relapse populations.

Keyphrases

circulating tumor
cell free
circulating tumor cells
squamous cell carcinoma
small cell lung cancer
cell migration
copy number
single cell
free survival
gene expression
risk assessment
single molecule