Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series.
Anna A NazarovaKseniya N SedenkovaDmitry S KarlovMstislav I LavrovYuri K GrishinTamara S KuznetsovaVladimir L ZamoyskiVladimir V GrigorievElena B AverinaVladimir A PalyulinPublished in: MedChemComm (2019)
The first example of a novel class of AMPA receptor positive allosteric modulators of the bis(pyrimidine) series having a hydroquinone linker has been obtained and showed a potency to increase kainate-induced currents at subnanomolar concentrations.