Role of IL-24 in NK cell activation and its clinical implication in systemic lupus erythematosus.
Yundi TangXiaotong SunYuxuan WangHuijie LuanRuijun ZhangFanlei HuXiaolin SunXia LiJianping GuoPublished in: Clinical rheumatology (2021)
Our data indicate that there were no significant differences in serum and plasma concentrations of IL-24 between SLE patients and healthy controls. Recombinant IL-24 has no effect on NK cell activation and migration. Key points • This is the first study to investigate functional potential of IL-24 on NK cell activation. • Recombinant IL-24 lacks functional capacity on NK cell activation in either CD56dimCD16+ or CD56brightCD16- NK cell subsets derived from both healthy subjects and patients with SLE. • No significant differences in serum and plasma levels of IL-24 between SLE patients and healthy controls.