Intravenous Glu-plasminogen attenuates cholesterol crystal embolism-induced thrombotic angiopathy, acute kidney injury and kidney infarction.

Lyuben LyubenovChongxu ShiDanyang ZhaoLuying YangYutian LeiElmina Mammadova-BachLetizia de ChiaraRoberto SemeraroSamuela LandiniPaola RomagnaniElena VörgSatish K DevarapuRicarda WelzStephan T KiessigHans-Joachim Anders

Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022)

These results provide the first experimental evidence that Glu-plasminogen could be an innovative therapeutic strategy to attenuate thrombotic angiopathy, AKI, kidney necrosis, and potentially other clinical manifestations of CC embolism syndrome.

Keyphrases

acute kidney injury
cardiac surgery
high glucose
diabetic rats
high dose
case report
drug induced
low density lipoprotein
endothelial cells