Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study.

Helena Bächle Peggy Sekula Pascal Schlosser Inga SteinbrennerYurong ChengFruzsina KotsisHelena StockmannHelena StockmannSebastian Schönherrnull nullKai Uwe Eckardt Olivier DevuystJürgen ScherberichAnna KöttgenUlla T Schultheiss

Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022)

We identified urinary metabolites associated with urinary and serum uromodulin. sUMOD and the sMS were associated with lower risk of adverse kidney events among CKD patients. Higher levels of sUMOD and sMS may reflect a higher number of functional nephrons and therefore a reduced risk of adverse kidney outcomes.

Keyphrases

chronic kidney disease
end stage renal disease
peritoneal dialysis
ms ms
ejection fraction
newly diagnosed
prognostic factors
emergency department
type diabetes
adipose tissue
insulin resistance
patient reported