Development of SERS Active Nanoprobe for Selective Adsorption and Detection of Alzheimer's Disease Biomarkers Based on Molecular Docking.
Umesh Chandra GarnaikAnshuman ChandraVijay Kumar GoelBalázs GulyásParasuraman PadmanabhanShilpi AgarwalPublished in: International journal of nanomedicine (2024)
This peptide-probe interaction provides a general enhancement factor and the molecular structure of the misfolded peptides. Secondary structural information may be obtained at the molecular level for specific residues owing to isotope shifts in the Raman spectra. Conjugation of the nanoprobe with Aβ42 selectively detected AD in bodily fluids. The proposed nanoprobes can be easily applied to the detection of Aβ plaques in blood, saliva, and sweat samples.
Keyphrases
- molecular docking
- label free
- living cells
- loop mediated isothermal amplification
- molecular dynamics simulations
- real time pcr
- single molecule
- gold nanoparticles
- raman spectroscopy
- sensitive detection
- cognitive decline
- healthcare
- health information
- fluorescence imaging
- density functional theory
- aqueous solution
- simultaneous determination
- solid phase extraction