Treatment of Hidradenitis Suppurativa Patient with Klinefelter Syndrome by Adalimumab.
Min Jeong ShinJeong Yeon HongHo Jung LeeChang Yoon SimYoung Lip ParkJong Suk LeeSung Yul LeeJung Eun KimPublished in: Annals of dermatology (2019)
Hidradenitis suppurativa (HS) is a chronic, inflammatory and painful skin disease with recurrent nodules and tracts involving the intertriginous regions. It is known that the patient with HS shows an increased risk of metabolic disorders such as diabetes, metabolic syndrome and autoimmune diseases. Klinefelter syndrome (KS) is a sex chromosomal disorder occurring in males due to an abnormality of sexual differentiation, characterized by 47, XXY karyotype. Also, KS is related with somatic comorbidities such as metabolic syndrome, autoimmune and rheumatologic disorders as HS is. We report a HS patient with KS who shows a big improvement while on tumor necrosis factor-alpha inhibitor treatment.
Keyphrases
- hidradenitis suppurativa
- metabolic syndrome
- case report
- rheumatoid arthritis
- type diabetes
- oxidative stress
- uric acid
- multiple sclerosis
- mental health
- cardiovascular risk factors
- gene expression
- copy number
- combination therapy
- big data
- machine learning
- skeletal muscle
- weight loss
- juvenile idiopathic arthritis
- ulcerative colitis