Single- vs. double-dose gadolinium contrast in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in knee osteoarthritis: is dose reduction possible on 3-T MRI?
Stine HangaardJesper Sörensson GadePhilip HansenJanus Damm NybingHenrik GudbergsenHenning BliddalMikael BoesenPublished in: Acta radiologica (Stockholm, Sweden : 1987) (2018)
We found a dose-response relationship between single and double doses of Gd-DTPA2- using 3-T in knee OA patients, similar to the findings at 1.5-T. Compared to the T1-relaxation time at 3-T without contrast (1240 ms), this further separation between OA and normal cartilage indicates that "single dose" dGEMRIC could be sufficient for cartilage health assessment at 3-T.
Keyphrases
- knee osteoarthritis
- contrast enhanced
- magnetic resonance imaging
- magnetic resonance
- end stage renal disease
- extracellular matrix
- computed tomography
- healthcare
- newly diagnosed
- diffusion weighted imaging
- chronic kidney disease
- public health
- mass spectrometry
- ejection fraction
- multiple sclerosis
- peritoneal dialysis
- liquid chromatography
- single molecule
- anterior cruciate ligament