Radiosensitization with Gadolinium Chelate-Coated Gold Nanoparticles Prevents Aggressiveness and Invasiveness in Glioblastoma.
Maxime DurandAlicia ChateauJustine JubréauxJérôme DevyHéna PaquotGautier LaurentRana BazziStéphane RouxNicolas RichetAurélie Reinhard-RuchPascal ChastagnerSophie PinelPublished in: International journal of nanomedicine (2023)
Combining Au@DTDTPA(Gd) nanoparticles and X-ray radiotherapy appears as an attractive therapeutic strategy to decrease number, viability and aggressiveness of tumor cells that escape and can invade the surrounding brain parenchyma. Hence, Au@DTDTPA(Gd)-enhanced radiotherapy opens up interesting perspectives for glioblastoma treatment.
Keyphrases
- gold nanoparticles
- reduced graphene oxide
- early stage
- locally advanced
- sensitive detection
- radiation therapy
- radiation induced
- high resolution
- resting state
- white matter
- squamous cell carcinoma
- magnetic resonance
- magnetic resonance imaging
- functional connectivity
- mouse model
- rectal cancer
- blood brain barrier
- brain injury
- cerebral ischemia