Outpatient Cryptococcal Antigen Screening is Associated with Favorable Baseline Characteristics and Improved Survival in Persons with Cryptococcal Meningitis in Uganda.
Anna E LevinAnanta S BangdiwalaElizabeth NalintyaEnock KagimuJohn KasibanteMorris K RutakingirwaEdward MpozaSamuel JjunjuEdwin NuwagiraRose NaluyimaPaul KirumiraCody R HouKenneth SsebambuliddeAbdu K MusubireDarlisha A WilliamsMahsa AbassiConrad MuzooraKatherine H HullsiekRadha RajasinghamDavid B MeyaDavid R BoulwareCaleb P SkipperPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Survival from cryptococcal meningitis was higher in persons with prior CrAg screening than those without CrAg screening. Altered mental status was the most potent predictor for mortality in a multivariate model. We suggest that CrAg screening detects cryptococcal meningitis at an earlier stage, as evidenced by a favorable baseline risk profile and notably fewer persons with altered mental status.