Gallic acid leads to cell death of Candida albicans by the apoptosis mechanism.
Ito LiberatoLeticia A LinoJuan Kd SouzaJoão Batista de Andrade NetoLívia G do Av SáVitória Pf CabralCecília R SilvaHélio V N JúniorManoel O MoraesValder N FreireClaudia R AndradePublished in: Future microbiology (2022)
Aim: To evaluate the antifungal activity of gallic acid (GA) against the strains of Candida spp. resistant to fluconazole and to determine its mechanism of action. Materials & methods: Antifungal activity was evaluated using the broth microdilution and flow cytometry techniques. Results: GA presented minimum inhibitory concentrations ranging from 16 to 72 μg/ml, causing alterations of the membrane integrity and mitochondrial transmembrane potential, production of reactive oxygen species and externalization of phosphatidylserine. Conclusion: GA has potential antifungal activity against Candida spp.