Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632.

Rima KoikeYoshihiro WatanabeKazuho KatoYudai MikasaKota ShimizuKenichi NonakaMasako HonshoTakuya SugaRei HokariAki IshiyamaYukihiro Asami Masato Iwatsuki

Published in: The Journal of antibiotics (2022)

Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity.

Keyphrases

high resolution
mass spectrometry
magnetic resonance
multiple sclerosis
ms ms
molecular docking
solid state