Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models.

Huaxin SunJie SongKai LiYao LiLuxiang ShangQina ZhouYanmei LuYazhen ZongXiuyuan HeMuzappar KariHang YangXianhui ZhouLing ZhangBao-Peng Tang

Published in: Clinical science (London, England : 1979) (2023)

Suppressing β1-AAbs effectively protects the atrial vulnerable substrate by ameliorating intracellular Ca2+ mishandling and atrial fibrosis, preventing the process of the autoimmune associated AF.

Keyphrases

atrial fibrillation
catheter ablation
left atrial
oral anticoagulants
left atrial appendage
direct oral anticoagulants
heart failure
percutaneous coronary intervention
multiple sclerosis
signaling pathway
liver fibrosis
mitral valve
left ventricular
structural basis
reactive oxygen species