CD8+ T-Lymphocyte-Driven Limbic Encephalitis Results in Temporal Lobe Epilepsy.
Julika PitschKaren M J van LooMarco GallusAndre DikDelara KamalizadeAnn-Kathrin BaumgartVadym GnatkovskyJohannes Alexander MüllerThoralf OpitzGordon HickingVenu Narayanan NaikLydia WachsmuthCornelius FaberRainer SurgesChristian KurtsSusanne SchochNico MelzerAlbert J BeckerPublished in: Annals of neurology (2021)
These data indicate that a CD8+ T-cell-initiated attack of distinct hippocampal neurons is sufficient to induce LE converting into TLE-HS. Intriguingly, the role of CD8+ T cells exceeds neurotoxic effects and points to their major pathogenic role in TLE following LE. ANN NEUROL 2021;89:666-685.