Correlation between auto/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients.
Massimiliano CastellazziSimone PatergnaniMariapina DonadioCarlotta GiorgiMassimo BonoraEnrico FainardiIlaria CasettaEnrico GranieriMaura PugliattiPaolo PintonPublished in: Journal of neuroinflammation (2019)
Serum levels of ATG5, Parkin, and lactate were more elevated in Gd+ than in Gd- MS patients (p < 0.0001), and CSF concentrations of ATG5 and Parkin were greater in Gd+ than in Gd- MS (p < 0.0001). Our results demonstrated that molecular markers of autophagy and mitophagy are increased in CSF of MS patients during the active phases of the disease and that these catabolic markers, together with lactate, are also remarkably augmented in blood suggesting a role of these processes in MS pathogenesis and the possible use of these molecules as biomarkers of disease activity.
Keyphrases
- multiple sclerosis
- end stage renal disease
- magnetic resonance imaging
- ejection fraction
- mass spectrometry
- chronic kidney disease
- newly diagnosed
- disease activity
- peritoneal dialysis
- ms ms
- systemic lupus erythematosus
- rheumatoid arthritis
- computed tomography
- cell death
- patient reported outcomes
- magnetic resonance
- white matter
- endoplasmic reticulum stress
- ankylosing spondylitis