Vitamin D and Respiratory Diseases : Based on 11th Dr. I. C. Verma Excellence in Research Award for Young Pediatricians Delivered as Oration on 15th Oct. 2023.
Jagdish Prasad GoyalPublished in: Indian journal of pediatrics (2023)
The significance of Vitamin D has been appreciated beyond bone health and calcium metabolism. The importance of Vitamin D in respiratory health has been recognized due to its immunomodulatory and anti-microbial properties. The hypothesis is that Vitamin D could have a significant role in the pathogenesis of respiratory diseases and may represent a novel preventive and therapeutic strategy. Furthermore, enumerable observational studies established the association of Vitamin D deficiency with respiratory diseases such as asthma, bronchiolitis, pneumonia, tuberculosis, etc. However, experimental studies have not shown the encouraging results. This brief review will summarize and discuss the synthesis and metabolism of Vitamin D, the prevalence of Vitamin D deficiency in children, its role in the pathogenesis of various childhood respiratory diseases, and an overview of the therapeutic trials assessing the role of Vitamin D supplementation in childhood respiratory diseases.
Keyphrases
- healthcare
- public health
- respiratory tract
- mental health
- mycobacterium tuberculosis
- emergency department
- young adults
- risk factors
- risk assessment
- optical coherence tomography
- pulmonary tuberculosis
- early life
- climate change
- cystic fibrosis
- hiv infected
- extracorporeal membrane oxygenation
- antiretroviral therapy
- acute respiratory distress syndrome
- case control
- drug induced